The ageing and the prolongation live duration of old nuclear power plants is an essential topic in term of safety challenges.

IRSN is involved in PERFROI, an international project to complete the safety knowledge in case of a loss of coolant accident.

IRSN presents the RESCUE project, a treatment strategy to deal with acute radiation syndrome.

Over the coming decades, a large number of nuclear reactors will be decommissioned and dismantled to enable environmental mediation.  
The aim of the H2020 LD SAFE project IRSN participates in is to characterize and review the assessment of the risks associated with the laser cutting technology.

Since the nuclear disaster at the Fukushima Daiichi complex in 2011, IRSN has conducted research as part of the PRIODAC program to examine procedures for administering stable iodine to people in the event of repeated or prolonged radioactive releases. The program, which aims to set forth guidelines to be used by the authorities in charge of protecting the population, has been extended for three more years.

IRSN takes part in an international crisis exercise jointly organized by France and the IAEA.